Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.

نویسندگان

  • J G Chafouleas
  • W E Bolton
  • A R Means
چکیده

Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.

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عنوان ژورنال:
  • Science

دوره 224 4655  شماره 

صفحات  -

تاریخ انتشار 1984