Effect of curcumin on triton WR 1339 induced hypercholesterolemia in mice

(3, 10 and 30 mg/kg, i.p.) produced a significant, dose dependent decrease in the MAP and heart rate of LRA ligated rats. Significant reduction in MAP and heart rate was observed in hypertensive rats treated with propranolol (30 mg/kg), atenolol (10 mg/kg), DPJ 890 (3 and 10 mg/kg) and DPJ 955 (10 and 30 mg/kg). The fall in the the MAP produced by DPJ 890 (10 mg/kg) was greater compared to atenolol and propranolol while the effect of DPJ 955 was less than that of atenolol but greater than that of propranolol (Table 1). The observed change in the MAP and heart rate in LRA ligated rats with DPJ 890 may be due to its stronger receptor (β 1 ) binding property compared to atenolol.