Antibodies as pharmacokinetic and metabolic modifiers of neurotoxicity.

Pluronic as nano-carier for drug delivery systems

A common approach for building a drug delivery system is to incorporate the drug within the nanocarrier that results in increased solubility, metabolic stability, and improved circulation time. However, recent developments indicate that selection of polymer nanomaterials can implement more than only inert carrier functions by being biological response modifiers. One representative of such mater...

Pre-Noun Modifiers as a Means to Describe Product Characteristics

The article deals with the characteristics of noun phrases functioning in pre-position. Pre-noun modifiers, or attributive modifiers, are among the high-capacity structures in the contemporary English language, as they enable to devoid of prepositions and to describe objects in a laconic way. The goal of this research was to analyze the way scholars interpret this linguistic structure today, as...

Pharmacokinetic (PK) and Pharmacodynamic Profiles of Artemisinin Derivatives Influence Drug Neurotoxicity in Animals

Cancer and inhibition of fatty acid oxidation

Recently, a “metabolic transformation” property with increased glycolytic rates (Warburg effect) was described for cancer cells. It has been shown that there is an active interaction between mutations of crucial enzymes involved in metabolic pathways and of oncogenes, whose effector proteins also exert metabolic functions. Interestingly, because many of these metabolic changes are confined to t...

Prediction of Lipophilicity and Pharmacokinetics of Chloroacetamides by Chemometric Approach

In this study, the existence of biological potential of selected N-(substituted phenyl)-2-chloroacetamides was examined none empirically, as was the possibility of applying simpleexperimental technique in predicting essential properties which affect the biological activityof the compounds. By applying the Lipinski and Ghose’s rules, it has been revealed that theexamined chloroacetamides fulfill...