Is TGFBR1*6A a susceptibility allele for nonsyndromic familial colorectal neoplasia?
نویسندگان
چکیده
Our analysis definitely excludes the possibility of the TGFBR1*6A allele increasing the risk of colorectal neoplasia in our sample population. A recent study validating linkage of colorectal cancer to chromosome 9q also excluded the TGFBR1*6A allele as a disease-causing variant in that sample. We conclude that there remains an unidentified susceptibility locus in the region 9q22.2-31.2.
منابع مشابه
Lack of an association between the TGFBR1*6A variant and colorectal cancer risk.
PURPOSE Recently a common variant of the TGFBR1 gene, TGFBR1*6A, has been proposed to act as a low-penetrance tumor susceptibility allele for colorectal cancer, but data from published studies with individually low statistical power are conflicting. To further evaluate the relationship between TGFBR1*6A and colorectal cancer risk, we have conducted a large case-control study and a meta-analysis...
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TGFBR1*6A is a common hypomorphic variant of the type I transforming growth factor (TGF)-beta receptor (TGFBR1), which transduces TGF-beta growth inhibitory signals less effectively than TGFBR1. Recent studies suggest that TGFBR1*6A confers a selective growth advantage to both normal appearing and cancerous epithelial cells in the presence of TGF-beta. We have previously shown that TGFBR1*6A is...
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BACKGROUND Numerous epidemiological studies have evaluated the association between TGFBR1 polymorphisms and the risk of cancer, however, the results remain inconclusive. To derive a more precise estimation of the relation, we conducted a comprehensive meta-analysis of all available case-control studies relating the TGFBR1*6A and IVS7+24G>A polymorphisms of the TGFBR1 gene to the risk of cancer....
متن کاملConstitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs
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A polymorphic allele in transforming growth factor h receptor 1 (TGFbR1) is hypothesized to increase risk of cancer (1). The allele, designated as TGFbR1*6A , results from the deletion of three alanines within a nine-alanine stretch in exon 1, and in vitro studies have shown that TGFbR1*6A is an impaired mediator of TGF-h antiproliferative signals compared with wild-type (TGFbR1*9A ; refs. 2, 3...
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 16 5 شماره
صفحات -
تاریخ انتشار 2007