Iridium-catalyzed asymmetric hydrogenation of pyrrolo[1,2-a]pyrazinium salts.
نویسندگان
چکیده
Highly enantioselective iridium-catalyzed hydrogenation of pyrrolo[1,2-a]pyrazinium salts has been achieved, providing a direct access to chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives with up to 95% ee. The key feature of the reaction is the addition of cesium carbonate, which increases the conversion and prohibits the racemization pathway of products.
منابع مشابه
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ورودعنوان ژورنال:
- Organic letters
دوره 16 12 شماره
صفحات -
تاریخ انتشار 2014