Neisseria gonorrhoeae infection: the problem of antibiotic resistance and treatment failure
نویسندگان
چکیده
Fanling Integrated Treatment Centre, 6/F, Fanling Health Centre, 2 Pik Fung Road, Fanling, New Territories Gonococcal infection is one of the commonly encountered sexually transmitted diseases. The emergence of antibiotic resistance has remained a challenge for a few decades. The third generation cephalosporins are now the first-line therapy in many regions, however, the reduction of the susceptibility to cephalosporins is likely to emerge and spread. The article summarizes the contemporary treatment recommendations, the current problem of treatment failure with cephalosporins and the report of local data.
منابع مشابه
Antibiotic-Resistant Neisseria gonorrhoeae Spread Faster with More Treatment, Not More Sexual Partners
The sexually transmitted bacterium Neisseria gonorrhoeae has developed resistance to all antibiotic classes that have been used for treatment and strains resistant to multiple antibiotic classes have evolved. In many countries, there is only one antibiotic remaining for empirical N. gonorrhoeae treatment, and antibiotic management to counteract resistance spread is urgently needed. Understandin...
متن کاملResistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins
Neisseria meningitidis and Neisseria gonorrhoeae are human pathogens that cause a variety of life-threatening systemic and local infections, such as meningitis or gonorrhoea. The treatment of such infection is becoming more difficult due to antibiotic resistance. The focus of this review is on the mechanism of reduced susceptibility to penicillin and other β-lactams due to the modification of c...
متن کاملSeminal Plasma Initiates a Neisseria gonorrhoeae Transmission State
Niche-restricted pathogens are evolutionarily linked with the specific biological fluids that are encountered during infection. Neisseria gonorrhoeae causes the genital infection gonorrhea and is exposed to seminal fluid during sexual transmission. Treatment of N. gonorrhoeae with seminal plasma or purified semen proteins lactoferrin, serum albumin, and prostate-specific antigen each facilitate...
متن کاملA study on the frequency of vaginal species of Mycoplasma genitalium, Gardnerella vaginalis and Neisseria gonorrhoeae among pregnant women by PCR technique
Bacterial vaginosis or non-specific vaginitis describes the disease caused by a change in the normal Flora of the vagina, which leads to the elimination of Lactobacilli, generating hydrogen peroxide and excess growth of bacteria, particularly anaerobic bacteria. This disease is the most prevalent infection of the female genital tract, and the rate of frequency of anaerobic bacteria, specificall...
متن کاملAnalysis of the potential impact of a point-of-care test to distinguish gonorrhoea cases caused by antimicrobial-resistant and susceptible strains of Neisseria gonorrhoeae
The 70-year history of antibiotics has been marked by the continual and seemingly inevitable rise of antibiotic resistance. Gonorrhoea, a sexually-transmitted bacterial infection, illustrates very well our constant ‘battle’ to overcome resistant bacteria and so treat drug-resistant infections. Because of the public health importance placed on limiting spread of this infection, a single dose of ...
متن کامل