Hereditary ovalocytosis in Melanesians.

Hereditary ovalocytosis in Malays.

Since the first description of hereditary ovalocytosis in Malayan aborigines 1 1965, high frequencies of hereditary ovalocytosis have been reported in South East Asia?,3 Biophysical studies showed a strong correlation between increased membrane rigidity and decreased malarial parasite invasion in hereditary ovalocytosis in the Malayan aborigines." The literature currently available describes he...

Homozygous haemoglobin E in association with hereditary ovalocytosis.

Hereditary stomatocytic ovalocytosis and haemoglobin E are two genes present in 3-5% of Malays. This is a report of a 22 year old Malay college student with homozygous haemoglobin E and hereditary stomatocytic ovalocytosis where the clinical effects seen were the result of the summation of these genes: he was asymptomatic, presenting with moderate jaundice, moderate hepatosplenomegaly, and a mi...

Rigid membranes of Malayan ovalocytes: a likely genetic barrier against malaria.

A high frequency of nonhemolytic hereditary ovalocytosis in Malayan aborigines is thought to result from reduced susceptibility of affected individuals to malaria. Indeed, Kidson et al. recently showed that ovalocytes from Melanesians in Papua New Guinea are resistant to infection in culture by the malarial parasite Plasmodium falciparum. In order to determine if protection against parasitic in...

Disorders of red cell membrane.

Studies during the last three decades have enabled the development of detailed molecular insights into the structural basis of altered function in various inherited red cell membrane disorders. This review highlights our current understanding of molecular and mechanistic insights into various inherited red cell membrane disorders involving either altered membrane structural organization (heredi...

Two families in Sri Lanka with Southeast Asian ovalocytosis.