Jak-stat

90 JAK-STAT Volume 1 issue 2 In this issue of JAK-STAT, we introduce a series of reviews overlooking the ever-expanding field of myocardial JAK-STAT signaling. The history of cardiac JAK-STAT research begins in the mid-nineties, when various groups began to focus their attention on how myocardial physiology was specifically regulated through JAK-STAT signaling. Interest in the area began to grow following initial observations by the groups of Kishimoto and Chien, who were among the first to show that cardiac myocytes possess a functional gp130/JAK-STAT system that was intimately involved in the regulation of cardiac hypertrophy. Not long after, it was appreciated that STAT cardiac activity could be regulated by a host of diverse factors, including cardiotrophin-1, angiotensin II, leukemia inhibitory factor (LIF) and insulin, all of which suggested a that diverse and interesting underlying biology was at play. Several groups went on to characterize the activities and downstream effects of STAT1 and STAT3 in a host of cardiovascular pathologies. In an exciting series of discoveries for the field, the JAK-STAT pathway was found to play a fundamental role in the protective effects of both preand postconditioning. The advent of cardiacspecific STAT-deficient mice further reinforced the essential requirement of STATs for normal myocardial functioning, an area in which the contributions of the late Helmut Drexler will be sorely missed. Recent discoveries such as the role of STATs in the development of cardiac stem cells and in controlling mitochondrial respiration have led to renewed enthusiasm in the field and set the stage for exciting times ahead in this area of cardiac research. In this issue of JAK-STAT, some of the foremost experts in the field have come together to present the state of play in cardiovascular JAK-STAT biology. Frias et al. discuss recent exciting data showing that the sphingosine-1 phosphate (S1P) component of high density lipoproteins (HDL) exerts strong cardioprotective activity through the recently characterized survivor activating factor enhancement (SAFE) pathway. Booz and colleagues tackle the difficult question of trying to understand the many modes of STAT3 activity in the heart and examine the issue of differential signaling downstream of IL-6 family cytokines. Knight et al. review the recent findings that have uncovered how STAT1 and STAT3 regulate myocardial cell death during I/R injury, post-infarct remodeling and ischemic conditioning. Kishore and Verma discuss the cardioprotective actions of STAT3 and in particular the recent finding that IL-10, acting though STAT3, promotes increases survival of endothelial JAK-STAT Getting to the heart of the matter