This is the Pre-Published Version A fluorescence resonance energy transfer (FRET)-based high throughput drug screening method for discovery of anti-cancer compounds from herbal medicine
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چکیده
Background and purpose: We report the development of a very efficient cell-based high
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Fluorescence resonance energy transfer assay for high-throughput screening of ADAMTS1 inhibitors.
A disintegrin and metalloprotease with thrombospondin type I motifs-1 (ADAMTS1) plays a crucial role in inflammatory joint diseases and its inhibitors are potential candidates for anti-arthritis drugs. For the purposes of drug discovery, we reported the development and validation of fluorescence resonance energy transfer (FRET) assay for high-throughput screening (HTS) of the ADAMTS1 inhibitors...
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