Two RFLPs in human inter-alpha-trypsin inhibitor heavy chain gene ITIH2 on chromosome 10.
نویسندگان
چکیده
SOURCE AND DESCRIPTION OF CLONE : The 0.8 kb Eco RI / Bam HI fragment of lambda HuHITI-9 (1) used as a probe codes for human heavy chain H2 of the inter-alpha-trypsin inhibitor (2). POLYMORPHISMS : Kpn 1 (GGTAC/C) identifies one invariant band at 8.5 kb and a diaJlelic polymorphism with DNA fragments at 26.0 kb or 20.0 kb. Msp I (C/CGG) identifies three invariant bands at 2.35 kb, 2.1 kb and 1.0 kb and a diallelic polymorphism with DNA fragments at 5.0 kb or 2.8 kb and 2.2 kb. CHROMOSOMAL LOCALISATION : The ITIH2 gene has been mapped to 10pl5 by in situ hybridization (iT. MENDELIAN INHERITANCE : Codominant segregation (fig.) was found for each polymorphism in two informative families.
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ورودعنوان ژورنال:
- Nucleic acids research
دوره 17 13 شماره
صفحات -
تاریخ انتشار 1989