Treatment of hypophosphataemic vitamin D-resistant rickets with massive doses of 1 alpha-hydroxy-vitamin D3 during childhood.
نویسندگان
چکیده
Plasma levels of 1,25 dihydroxy-vitamin D (1,25-(OH)2-D) were low in 3 children with hypophosphataemic vitamin D-resistant rickets (HVDRR) during childhood, but increased after very large doses (0.5 to 2 micrograms/kg per day) of 1 alpha-hydroxy-vitamin D (1 alpha-OH-D3). This treatment has two advantages. Firstly, hypercalcaemia is easily controlled by reducing the dose of 1 alpha-OH-D3 because of its short half-life. Secondly, the administration of 1 alpha-OH-D3 to patients with HVDRR can enhance the tubular reabsorption of phosphate, and this seems desirable in treating HVDRR.
منابع مشابه
Treatment of hypophosphataemic vitamin D - resistant rickets with massive doses of 1 a . - hydroxy - vitamin D 3 during childhood
Plasma levels of 1,25 dihydroxy-vitamin D (1,25-(OH)2-D) were low in 3 children with hypophosphataemic vitamin D-resistant rickets (HVDRR) during childhood, but increased after very large doses (0 * 5 to 2 ,g/kg per day) of 1 ao-hydroxy-vitamin D (1 ac-OH-D3). This treatment has two advantages. Firstly, hypercalcaemia is easily controlled by reducing the dose of oc-OH-D3 because of its short ha...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 55 1 شماره
صفحات -
تاریخ انتشار 1980