Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma
نویسندگان
چکیده
OY-TES-1 is a member of the cancer/testis antigen family that is expressed in healthy testis tissue and certain types of cancerous tissue. The present study aimed to analyze the expression pattern of OY-TES-1 and serum anti-OY-TES-1 antibody concentration in patients with glioma. OY-TES-1 mRNA was detected in 28/36 (78%) of glioma cases using conventional reverse transcription polymerase chain reaction (RT-PCR) analysis. RT-quantitative-PCR revealed that OY-TES-1 was expressed at a higher level in glioma tissues compared with normal adult tissues (with the exception of testis tissue). Anti-OY-TES-1 antibodies were present in the serum of 5/36 (14%) of patients with glioma, but absent in all the serum samples from 107 healthy donors. Immunohistochemical analysis demonstrated that OY-TES-1 protein was expressed in all glioma tissues from patients with anti-OY-TES-1 antibody seropositivity. These results suggest that OY-TES-1 is a novel candidate for glioma immunotherapy.
منابع مشابه
Expression status and prognostic value of cancer/testis antigen OY-TES-1 in glioma
Cancer testis (CT) antigens are attractive therapeutic targets for tumor immunotherapy because of their restrictive expression in normal tissues and excessive in majority of tumor types. OY-TES-1 is a member of the cancer/testis (CT) antigen family. Current research about OY-TES-1 expression in glioma is practically at mRNA level. The role of OY-TES-1 protein in glioma has not yet been describe...
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