24 Common and Rare Variation in the T Helper 2 Gene Pathway Predicts Allergic Asthma Phenotypes

multi gene family), showed significant sequence and structural similarity to Cyn d 1. This protein was expressed in E. coli and the recombinant protein did not react with serum IgE from grass pollen allergic patients, suggesting that EXPB1 represented a non-allergenic homologue of grass group 1 allergens. It is proposed that differences in the amino acid sequence are responsible for the difference in the allergenicity profile of the Arabidopsis and grass pollen proteins. Conclusions: Our study provides valuable data for further investigations of the molecular basis of allergenicity and cross-reactivity of grass group 1 allergens.