Formulation Development and In-vitro Evaluation of Minoxidil Bearing Glycerosomes

Present study was undertaken to assess the potential of Glycerosomes as a novel drug delivery system for topical application of Minoxidil. Pre-formulation studies were done for identification of drug as well as for determination of its physiochemical properties. Spectra of various mixtures of drug and excipients do not show any additional peak thus, indicating compatibility with each other. Glycerosomes was prepared by using lipid thin film hydration method. Prepared formulations were evaluated in terms of particle size, surface analysis, zeta potential, entrapment efficiency and in-vitro drug release. The formulated Glycerosomes were found to have better surface characteristics and entrapment efficiency. The in vitro drug dissolution study was carried out using egg membrane on modified franz diffusion cell and the release mechanisms were explored. The release data was incorporated into various mathematical models and the formulation follows Higuchi as well as Fickian diffusion. Results study proved that Glycerosomes containing Minoxidil can be an excellent therapy for Alopecia.