Cyclosporine in the Treatment of Steroid Resistant Severe Ulcerative Colitis: A Word of Caution

نویسنده

  • Amir Hussain
چکیده

Cyclosporine may be considered as state of the art treatment for steroid resistant severe ulcerative colitis. Up to 30-40% of the patients with severe ulcerative colitis will fail to respond to intravenous steroid treatment and would require surgical treatment. I report a case of steroid resistant severe ulcerative colitis, which failed to respond to cyclosporine due to presence of cytomegalovirus infection causing ischaemic colitis that had been seen on histopathological examination.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Patient and health professionals’ perspectives on the use of ciclosporin and infliximab when treating acute severe ulcerative colitis: an added dimension to the construct trial

Aim The COmparison Of iNfliximab and ciclosporin in STeroid Resistant Ulcerative Colitis Trial (CONSTRUCT) aimed to compare the clinical and cost effectiveness of infliximab and ciclosporin in the treatment of steroid resistant acute severe ulcerative colitis, using quantitative, qualitative, and health economic data. The qualitative element explored patients’ and health professionals’ views of...

متن کامل

گزارش درمان شش مورد کولیت اولسروز مقاوم به درمان استاندارد با سیکلوسپرین

Background and purpose: Treatment of refractory ulcerative colitis (ÜÇ) is a problem in the intestinal tract diseases. Different researches have shown that intravenous administration of cyclosporine before surgical operation can be effective. But less is known about the oral administration of cyclosporine given at the onset of the treatment of refractory ÜÇ. Ïn this study effectiveness and si...

متن کامل

Predictive factors of poor response to intravenous cyclosporine in steroid-refractory ulcerative colitis.

BACKGROUND The treatment of severe ulcerative colitis (UC) flares includes measures such as hospitalization and intravenous steroids. Despite this, a quarter of patients are refractory to treatment. Given the availability of new therapeutic strategies in patients with steroid-refractory UC (cyclosporine, infliximab, apheresis, surgery) it is necessary to predict which treatment will be most eff...

متن کامل

Economic Evaluation of Infliximab for Treatment of Refractory Ulcerative Colitis in Iran: Cost-Effectiveness Analysis

The aim of this study is to assess cost-effectiveness of infliximab, compared with conventional treatments in patients with moderate to severe Ulcerative Colitis (UC) in Iran. We developed an analytical decision model with a 5-year-time horizon to follow up 1000 hypothetical patients, in order to estimate treatment costs and outcomes. Hypothetical patients, were individuals with moderate to sev...

متن کامل

Does the Cyclosporine Still Have a Potential Role in the Treatment of Acute Severe Steroid-Refractory Ulcerative Colitis?

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon characterized by diffuse mucosal inflammation. Acute severe colitis, a potentially lethal condition requiring hospitalization and intensive medical treatment can develop in 18% to 25% of patients with UC. Although intravenous corticosteroids are the mainstay of conventional medical treatment in this condition, about 30% to 4...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014