Vascular Signaling by Free Radicals Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
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چکیده
David A. Wink,1 Katrina M. Miranda,2 Tatsuo Katori,3 Daniele Mancardi,1 Douglas D. Thomas,1 Lisa Ridnour,1 Michael G. Espey,1 Martin Feelisch,4 Carol A. Colton,5 Jon M. Fukuto,6 Pasquale Pagliaro,7 David A. Kass,3 and Nazareno Paolocci3 1Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892; 2Department of Chemistry, University of Arizona, Tucson, Arizona 85721; 3Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287; 4Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130; 5Division of Neurology, Duke University Medical Center, Durham, North Carolina 27710; 6Department of Molecular and Medical Pharmacology, Center for the Health Sciences, University of California, Los Angeles, California 90095; and 7Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, 10041 Orbassano, Italy
منابع مشابه
The Orthogonal Properties of the Redox Siblings Nitroxyl (HNO) and Nitric Oxide (NO) in the Cardiovascular System: A Novel Redox Paradigm
Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions. An imbalance in the production or availability of these species can result in progression of disease. Nitrogen oxide research in the cardiovascular system has primarily focused on the effects of NO and higher oxidation products. However, nit...
متن کاملOrthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm.
Endogenous formation of nitric oxide (NO) and related nitrogen oxides in the vascular system is critical to regulation of multiple physiological functions. An imbalance in the production or availability of these species can result in progression of disease. Nitrogen oxide research in the cardiovascular system has primarily focused on the effects of NO and higher oxidation products. However, nit...
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Nitroxyl (HNO), the one electron reduced and protonated form of nitric oxide (NO(•)), is rapidly emerging as a novel nitrogen oxide with distinct pharmacology and therapeutic advantages over its redox sibling. Whilst the cardioprotective effects of HNO in heart failure have been established, it is apparent that HNO may also confer a number of vasoprotective properties. Like NO(•), HNO induces v...
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In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eNOS is uncoupled due to S-glutathionylation of critical cysteine residues, resulting in superoxide free radical formation instead of the vasodilator...
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Favaloro JL, Kemp-Harper BK. Redox variants of NO (NO and HNO) elicit vasorelaxation of resistance arteries via distinct mechanisms. Am J Physiol Heart Circ Physiol 296: H1274–H1280, 2009; doi:10.1152/ajpheart.00008.2009.—The free radical form of nitric oxide (NO ) is a well-known mediator of vascular tone. What is not so well recognized is that NO exists in several different redox forms. There...
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تاریخ انتشار 2003