Double-Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration.
نویسندگان
چکیده
On implanting hydroxyapatite-mineralized tough hydrogel into osteochondral defects of rabbits, osteogenesis spontaneously penetrates into the gel matrix owing to the semi-permeablility of the hydrogel. The gradient layer (around 40 μm thick) contributes quite strong bonding of the gel to bone. This is the first success in realizing the robust osteointegration of tough hydrogels, and the method is simple and feasible for practical use.
منابع مشابه
Fracture Mechanics Fatigue of Double - Network Hydrogels
The discovery of tough hydrogels of many chemical compositions, and their emerging applications in medicine, clothing, and engineering, has raised a fundamental question: How do hydrogels behave under many cycles of stretch? This paper initiates the study of the fatigue behavior of the classic PAMPS/PAAM double network hydrogels discovered by Gong and her co-workers (Advanced Materials 15, 1155...
متن کاملThe mechanical properties and cytotoxicity of cell-laden double-network hydrogels based on photocrosslinkable gelatin and gellan gum biomacromolecules.
A major goal in the application of hydrogels for tissue engineering scaffolds, especially for load-bearing tissues such as cartilage, is to develop hydrogels with high mechanical strength. In this study, a double-network (DN) strategy was used to engineer strong hydrogels that can encapsulate cells. We improved upon previously studied double-network (DN) hydrogels by using a processing conditio...
متن کاملAssociation of Behçet’s Disease with Osteogenesis Imperfecta in A Ten-Year-Old Girl
Osteogenesis Imperfecta (OI) is a genetic disorder characterized by bones that break easily, often from little or no apparent cause. In this article, we present a patient suffering from OI, who had concomitant active Behçet’s Disease(BD)with repeated oro-genital ulcers, skin postular eruptions and severe recurrent bilateral uveitis. This patient, is, to our knowledge the first reported case in ...
متن کاملBioactive nanoengineered hydrogels for bone tissue engineering: a growth-factor-free approach.
Despite bone's impressive ability to heal after traumatic injuries and fractures, a significant need still exists for developing strategies to promote healing of nonunion defects. To address this issue, we developed collagen-based hydrogels containing two-dimensional nanosilicates. Nanosilicates are ultrathin nanomaterials with a high degree of anisotropy and functionality that results in enhan...
متن کاملOptical tweezers reveal relationship between microstructure and nanoparticle penetration of pulmonary mucus.
In this study, the mobility of nanoparticles in mucus and similar hydrogels as model systems was assessed to elucidate the link between microscopic diffusion behavior and macroscopic penetration of such gels. Differences in particle adhesion to mucus components were strongly dependent on particle coating. Particles coated with 2 kDa PEG exhibited a decreased adhesion to mucus components, wherea...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Advanced materials
دوره 28 31 شماره
صفحات -
تاریخ انتشار 2016