Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon.
نویسندگان
چکیده
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.
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ورودعنوان ژورنال:
- Journal of virology
دوره 74 7 شماره
صفحات -
تاریخ انتشار 2000