Homocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
نویسنده
چکیده
The Writing Group (Eva Lonn, M.D., and Salim Yusuf, D.Phil., M.B., B.S., Population Health Research Institute, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont.; Malcolm J. Arnold, M.D., Department of Medicine, Division of Cardiology, University of Western Ontario, London; Patrick Sheridan, M.Sc., Janice Pogue, M.Sc., and Mary Micks, C.T.R.C., Population Health Research Institute, McMaster University, Hamilton, Ont.; Matthew J. McQueen, M.D., Ph.D., Pathology and Molecular Medicine, McMaster University, Hamilton, Ont.; Jeffrey Probstfield, M.D., University of Washington School of Medicine, Seattle; George Fodor, M.D., Ph.D., University of Ottawa Heart Institute, Ottawa; Claes Held, M.D., Ph.D., Department of Cardiology, Karolinska University Hospital, Stockholm; and Jacques Genest, Jr., M.D., Division of Cardiology, McGill University Health Center and Royal Victoria Hospital, Montreal) assumes responsibility for the overall content and integrity of the manuscript. Address reprint requests to Dr. Lonn at the Population Health Research Institute, Hamilton General Hospital, 237 Barton St. East, Hamilton, ON L8L 2X2, Canada, or at [email protected].
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High plasma homocysteine is identified as an important risk factor for cardiovascular disease. Epidemiological studies have shown that increased plasma homocysteine is related to a higher risk of coronary heart disease, stroke and peripheral vascular disease. Homocysteine may have an effect on atherosclerosis by damaging the inner lining of arteries and promoting blood clots .Folic acid and oth...
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On the basis of recent retrospective and prospective studies, it is now widely accepted that increased total plasma homocysteine is a risk factor for cardiovascular disease. Impaired enzyme function as a result of genetic mutation or deficiency of the essential B vitamins folic acid, B12, and B6 can lead to hyperhomocysteinemia. Oxidized forms of homocysteine account for 98-99% of total plasma ...
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متن کامل[Homocysteine lowering with folic acid and B vitamins in vascular disease].
BACKGROUND In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease. METHODS We randomly assigned 5522 patients 55 years of age or older who had vascu...
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