High Level Resistance to Aminoglycosides in Urinary Isolates of Enterococci
نویسندگان
چکیده
Sir, Enterococci have become important nosocomial pathogens world-wide and are associated with a high mortality. The treatment of these infections poses a great challenge due to the inherent resistance of Enterococci to many antibiotics.[1] Infections by Enterococci have traditionally been treated with cell wall active agents in combination with an aminoglycoside; however, the emergence of high level resistance to aminoglycosides (HLAR), beta lactam antibiotics and to vancomycin by some strains, together with association of HLAR with the multidrug resistance has led to failure of synergistic effects of combination therapy.[2]
منابع مشابه
Anti-Microbial Resistance of Enterococci Isolated from Urinary Tract Infections in Iran
Background: During the last decade, enterococci have become important nosocomial pathogens, representing the second leading cause of urinary tract infections. This increasing prevalence has been paralleled by the occurrence of multi-drug resistant (MDR) and high-level gentamicin resistant (HLGR) strains. Methods: From September 2005 to 2006, a total of 638 enterococcal isolates were collected ...
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Introduction & Objective: Enterococci have emerged as the leading nosocomial pathogens. In addition to natural resistance to many agents, enterococci have also developed plasmid- and transposon-mediated resistance to high concentrations of aminoglycosides. High-level gentamicin resistance (HLGR) of enterococci results in the failure of drug synergism with an aminoglycoside plus cell-wall-acti...
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