Prognostic Significance of Cystatin C in Coronary Artery Disease
نویسندگان
چکیده
Cystatin C, an established marker of renal dysfunction, is gaining importance in dysfunction of other organs (systems) as well. Preliminary studies indicated a role for cystatin C as a prognostic marker in coronary artery disease (CAD). The aim of the study was to assess the of serum cystatin C levels in CAD cases and its comparison with controls. Comparison of serum cystatin C levels in CAD spectrum. Comparison of serum cystatin C levels in CAD cases based on risk factors,body mass index (BMI) and waist circumferance(WC).cystatin C levels in CAD cases based on risk factors,body mass index (BMI) and waist circumferance(WC). Study group comprised of 145 patients diagnosed as having CAD based on clinical and bio-chemical criteria. Control group included 66 age and sex matched subjects (non CAD cases) using the above mentioned criteria. In this study, significant increase of mean serum cystatin C levels was observed in CAD cases than controls. Highest mean cystatin C values were observed in Myocardial infarction (MI) than Unstable angina (UA) and Stable angina (SA).Highest mean cystatin C values were CAD cases with risk factors. Highest mean cystatin C values were CAD with increased BMI and WC. Cystatin C plays an important role in the development of CAD and serum cystatin C is a might have a role as a prognostic marker in patients with CAD.
منابع مشابه
Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease.
OBJECTIVE Overexpression of elastolytic cysteine and aspartic proteases, known as cathepsins, is implicated in atherogenesis. The potential significance of imbalance in expression between cathepsins and their inhibitor cystatin C in cardiovascular disease has been highlighted by the demonstration of cystatin C deficiency in human atherosclerosis and abdominal aortic aneurysms. METHODS AND RES...
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