Out of the active site binding pocket for carbonic anhydrase inhibitors.
نویسندگان
چکیده
A structural study of the adduct which 2-benzylsulfinylbenzoic acid forms with human carbonic anhydrase II is reported, showing a binding mode completely different from any other class of carbonic anhydrase inhibitors investigated so far; this carboxylate binds in a pocket situated out of the enzyme active site.
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 2 شماره
صفحات -
تاریخ انتشار 2015