Ethyl 3-(4-fluoro­phen­yl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydro­furo[2,3-d]pyrimidine-5-carboxyl­ate

نویسندگان

  • Yong Sun
  • Guo-Ping Zeng
  • Yang-Gen Hu
چکیده

In the crystal structure of the title compound, C(22)H(24)FN(3)O(4), the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclo-hexyl ring shows a distorted chair conformation. The mol-ecular structure is stabilized by intra-molecular C-H⋯O and C-H⋯N hydrogen-bonding inter-actions. The crystal packing is mainly stabilized by C-H⋯π hydrogen-bond inter-actions. Further stability is provided by C-F⋯π and C-O⋯π stacking inter-actions.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ethyl 2-isopropyl­amino-5-methyl-4-oxo-3-phenyl-3,4-dihydro­thieno[2,3-d]pyrimidine-6-carboxyl­ate

The title compound, C(19)H(21)N(3)O(3)S, was synthesized via an aza-Wittig reaction of a functionalized imino-phospho-rane with phenyl isocyanate under mild conditions. In the mol-ecule, the fused thienopyrimidine ring system makes a dihedral angle of 66.30 (11)° with the phenyl ring. An intra-molecular C-H⋯O hydrogen bond occurs. The terminal -OCH(2)CH(3) group is disordered over two sites wit...

متن کامل

Ethyl 5-methyl-4-oxo-3-phenyl-2-propyl­amino-3,4-dihydro­thieno[2,3-d]pyrimidine-6-carboxyl­ate

The title compound, C(19)H(21)N(3)O(3)S, was synthesized via the aza-Wittig reaction of functionalized imino-phospho-rane with phenyl isocyanate under mild conditions. In the mol-ecule, the fused thienopyrimidine ring system is essentially planar, with a maximum deviation of 0.072 (2) Å, and makes a dihedral angle of 60.11 (9)° with the phenyl ring. An intra-molecular C-H⋯O hydrogen bond is pre...

متن کامل

Ethyl 2-(4-carb­oxy­benzyl­idene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-thia­zolo[3,2-a]pyrimidine-6-carboxyl­ate–N,N-dimethyl­formamide (1/1)

In the title compound, C(24)H(20)N(2)O(5)S·C(3)H(7)NO, a benzene ring is positioned axially to the pyrimidine ring, which adopts a twist-boat conformation, and is inclined to its mean plane by 85.36 (7)°. In the crystal, inter-molecular C-H⋯O inter-actions result in centrosymmetric head-to-head dimers with an R(2) (2)(14) graph-set motif along the b axis. Pairs of C-H⋯O and O-H⋯O hydrogen bonds...

متن کامل

Synthesis of a new series of pyridine and fused pyridine derivatives.

The reaction of 4-methyl-2-phenyl-1,2-dihydro-6-oxo-5-pyridine- carbonitrile (1) with arylidene malononitrile afforded isoquinoline derivatives 2a,b. 6-Chloro-4-methyl-2-phenyl-5-pyridinecarbonitile (3) obtained by chlorination of compound 1 with phosphoryl chloride was converted into 6-amino-4-methyl-2-phenyl-5-pyridinecarbonitrile (4) and 6-hydrazido-4-methyl-2-phenyl-5-pyridinecarbonitrile (...

متن کامل

Photochemistry of Pesticides, 10 [1] Photodegradation of 0,0-DiethyI-S(3,4-dihydro-4-oxobenzo[d][l,2,3]triazin- 3-yl-methyl)phosphorodithioate (Azinphos-ethyl)

The photodegradation of Azinphos-ethyl (1) in chloroform and methanol solution has been studied. 3,4-D ihydro-3-m ethyl-4-oxobenzo[d][l,2,3]triazine (3), 3,4-dihydro-4-oxo-benzo[d][l,2,3]triazine (5), 0 ,0-d iethyl-0(3-m ethylbenzo[d][l,2 ,3]triazine-4-yl)phosphate (8), N-methylanthranilic acid (11) (in methanol: methyl ester 12), and sulfur have been isolated and charac­ terized as photoproduc...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 64  شماره 

صفحات  -

تاریخ انتشار 2007