Autonomic and behavioral thermoregulation in guinea pigs during postnatal maturation.

Thermoregulation in rats during early postnatal maturation: importance of nitric oxide.

Experiments were carried out to determine the role of nitric oxide in mediating autonomic and behavioral thermoregulatory control in rat pups on postnatal days 1-2, 5-6, and 10-11. For an experiment, each pup received a subcutaneous injection of vehicle, NG-nitro-D-arginine methyl ester (D-NAME; 100 mg/kg), or NG-nitro-L-arginine methyl ester (L-NAME; 100 mg/kg) before being placed in a metabol...

Effect of vitamin C on tracheal responsiveness and pulmonary inflammation in chronic obstructive pulmonary disease model of guinea pig

Introduction: In the present study, the prophylactic effect of vitamin C, as a potent anti-oxidant, on tracheal responsiveness to methacholine and ovalbumin, bronchoalveolar lavage fluid white blood cell (WBC) count and differential count, and also lung pathology in chronic obstructive pulmonary disease (COPD) -guinea pigs (cigarette exposed guinea pigs) were examined. In addition, the relax...

A comparison of virulence of intraperitoneal infection of Burkholderia mallei strains in guinea-pigs

Male guinea pigs show high susceptibility to Burkholderia mallei and have been used as animal models in glanders studies. The purpose of our study was to elucidate glanders comparative pathogenesis in guinea pigs. We present here the histological changes and bacterial isolation that develop over time in guinea pigs inoculated intraperitoneally (IP) with two strain of B. mallei. Ten male guinea ...

Effect of substitute milk on growth and breeding rates of hysterectomy derived guinea pigs neonates

In this study, considering the normal ingredients in guinea pig's milk, by using cow milk, mixture of vitamins and minerals, a milk substitute was prepared and sterilized by autoclaving and filtration methods. In food analysis of produced milk, the important substances values, such as protein, fat and ash, were suitable. Milk substitute was fed to four groups of newborn's guinea pigs that were ...

Evaluation of Acute Aflatoxicosis on Humoral Immune Response to Foot-and Mouth Disease Vaccination in Guinea Pigs