The Role of BRCA1 in DNA Double-strand Break Repair
نویسندگان
چکیده
منابع مشابه
BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks.
BRCA1 is critical for the maintenance of genomic stability, in part through its interaction with the Rad50.Mre11.Nbs1 complex, which occupies a central role in DNA double strand break repair mediated by nonhomologous end joining (NHEJ) and homologous recombination. BRCA1 has been shown to be required for homology-directed recombination repair. However, the role of BRCA1 in NHEJ, a critical path...
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