Phyllanthus emblica L. Branch Extract Ameliorates Testicular Damage in Valproic Acid-Induced Rats El Extracto de la Rama de Phyllanthus emblica L. disminuye el Daño Testicular Inducido por Ácido Valproico en Ratas
نویسندگان
چکیده
Valproic acid (VPA), widely used in treating epileptic patients, can damage reproductive parameters causing male infertility. This study aimed to investigate protective effect of Phyllanthus emblica L. branch (PE) extract on rat testicular damage induced with VPA. Male rats were divided into 6 groups (control, VPA, 250 mg/kgBW PE only, and 50, 100, 250 mg/kgBW PE+VPA, respectively). Animals were pretreated with PE for 23 days and co-administered with VPA for 10 days before all reproductive parameters were determined. The results showed all doses of PE significantly protected the decrease testicular weight and testosterone level in VPA rats. PE significantly improved the decrease sperm concentration in VPA treated rats. Moreover, testicular histology of PE+VPA groups showed declining of testicular histopathologies as compared to VPA group. Therefore, it seems that PE branch extract can prevent testicular damages including male reproductive parameters in rats induced with VPA.
منابع مشابه
Antioxidants of Phyllanthus emblica L. Bark Extract Provide Hepatoprotection against Ethanol-Induced Hepatic Damage: A Comparison with Silymarin
Phyllanthus emblica L. (amla) has been used in Ayurveda as a potent rasayan for treatment of hepatic disorders. Most of the pharmacological studies, however, are largely focused on PE fruit, while the rest of the parts of PE, particularly, bark, remain underinvestigated. Therefore, we aimed to investigate the protective effect of the hydroalcoholic extract of Phyllanthus emblica bark (PEE) in e...
متن کاملAntioxidant potential of Phyllanthus fraternus Webster on cyclophosphamide induced changes in sperm characteristics and testicular oxidative damage in mice.
Cyclophasphamide (CPA) is used to treat various types of cancer. It is a cytotoxic alkylating agent widely used in chemotherapeutic regimen. However, the clinical efficacy of CPA is marred by its side effects. In clinical applications of CPA, it becomes necessary to prevent the oxidative stress and reproductive toxicity induced thereby in normal cells. In the present study, we investigated the ...
متن کاملAmelioration of alcohol-induced oxidative stress by Emblica officinalis (amla) in rats.
The present study was aimed at investigating the ameliorative effect of Emblica (Phyllanthus Emblica L) fruit extract (EFE) against alcohol-induced oxidative changes in plasma biochemical profile in rats. Alcohol administration (5 g/kg body wt/day) for 60 days resulted in significantly (P<0.05) higher levels of plasma nitrite/nitrate (NOx), total bilirubin, creatinine, and abnormalities in lipi...
متن کامل710-715 Gamez 1472:Gamez
D-004, a lipid extract from royal palm (Roystonea regia) fruits, has shown to inhibit prostate 5-α-reductase in vitro, and to prevent prostate hyperplasia (PH) induced with T, not with DHT, in rodents, but its potential estrogenic or antiestrogenic effects had not been studied yet. This study investigated whether D-004 produces estrogenic or antiestrogenic effects, as assessed in the uterotroph...
متن کاملTotal Flavonoid Determination for the Quality Control of Aqueous Extractives from Phyllanthus niruri L
The purpose of this study has been the development of an adequate methodology for the quality control of Phyllanthus niruri aqueous extracts. The assay method was tested, with various modifications, to determine its suitability for the quantitative determination of total flavonoids within the crude drug raw material and aqueous extracts. The assay technique for such chemical group is based on t...
متن کامل