Lipocalin-2 and insulin resistance Lipocalin-2 deficiency attenuates insulin resistance associated with ageing and obesity Running title: Lipocalin-2 and insulin resistance
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چکیده
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes in print and online at http://diabetes.diabetesjournals.org. Diabetes Publish Ahead of Print, published online January 12, 2010
منابع مشابه
Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity
OBJECTIVE The proinflammatory cytokines/adipokines produced from adipose tissue act in an autocrine and/or endocrine manner to perpetuate local inflammation and to induce peripheral insulin resistance. The present study investigates whether lipocalin-2 deficiency or replenishment with this adipokine has any impact on systemic insulin sensitivity and the underlying mechanisms. METHODS AND RESU...
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PURPOSE Lipocalin-2 (Lcn2) has been recognized as an adipocyte-derived acute phase protein that is positively correlated with obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. The effects of resistance and endurance training (RT vs. ET) on plasma lipocalin-2 are still unclear. Therefore, the purpose of this study was to examine the effects of RT vs. ET on plasma lipocali...
متن کاملThe effects of obesity and polycystic ovary syndrome on serum lipocalin-2 levels: a cross-sectional study
BACKGROUND Lipocalin-2 is a novel adipokine that appears to play a role in the development of insulin resistance. Serum lipocalin-2 levels are elevated in obese patients. Obesity and insulin resistance are cardinal characteristics of the polycystic ovary syndrome (PCOS). However, there are limited data on serum lipocalin-2 levels in patients with PCOS. The aim of the present study was to assess...
متن کاملLipocalins and insulin resistance: etiological role of retinol-binding protein 4 and lipocalin-2?
The prevalence of type 2 diabetes is increasing dramatically worldwide. Excess adiposity is an important contributor to the development of type 2 diabetes and cardiovascular diseases (1 ). Insulin resistance, inflammation, hypertension, and dyslipidemia, components of the metabolic syndrome, have been implicated in the effects of adiposity on type 2 diabetes and cardiovascular diseases, but the...
متن کاملLipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans.
BACKGROUND Lipocalin-2, a 25-kDa secreted glycoprotein, is a useful biomarker for early detection of various renal injuries. Because lipocalin-2 is abundantly expressed in adipose tissue and liver, we investigated its relevance to obesity-related pathologies. METHODS We used real-time PCR and in-house immunoassays to quantify the mRNA and serum concentrations of lipocalin-2 in C57BL/KsJ db/db...
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