Development of Microparticle Loaded Gel (MPLGs) for Prolong Ocular Drug Delivery Containing Ketorolac Tromethamine

Microparticles loaded gels (MPLGs) are colloidal drug carriers in the microand submicron range. These systems were developed to overcome solubility problems of poorly soluble drugs as well as for long acting injectable depot formulations and specific drug targeting options. The main objective for these systems was to improve the classical aqueous eye drop formulations which have major disadvantages like a rapid elimination of the drugs from the precorneal area. Consequently, colloidal carrier microparticles were designed to combine ophthalmic prolonged action with the ease of the application of liquid eye gels. The applications of ketorolac tromethamine microparticles loaded gels are presented with focus on reduction of ocular pain and burning/stinging following corneal refractive surgery. The viscosities of microparticles loaded gel were found to be in the range (1500 to 1900 Cps). The maximum gel strength and mucoadhesion was found to be up to (40.79 seconds) and (26.66 dynes/cm) respectively. The value of ‘r’ for Higuchi kinetics which ranged from 0.989 to 0.990. It was understood that F code formulation were following predominantly zero order release.