Neurobiology of Disease Enhancing Astrocytic Lysosome Biogenesis Facilitates A Clearance and Attenuates Amyloid Plaque Pathogenesis
نویسندگان
چکیده
Qingli Xiao,1 Ping Yan,1 Xiucui Ma,2,3 Haiyan Liu,2 Ronaldo Perez,1 Alec Zhu,1 Ernesto Gonzales,1 Jack M. Burchett,1 Dorothy R. Schuler,1 John R. Cirrito,1 Abhinav Diwan,2,3* and Jin-Moo Lee1* 1Department of Neurology and the Hope Center for Neurological Disorders and 2Division of Cardiology and Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, and 3John Cochran VA Medical Center, St. Louis, Missouri 63108
منابع مشابه
Enhancing astrocytic lysosome biogenesis facilitates Aβ clearance and attenuates amyloid plaque pathogenesis.
In sporadic Alzheimer's disease (AD), impaired Aβ removal contributes to elevated extracellular Aβ levels that drive amyloid plaque pathogenesis. Extracellular proteolysis, export across the blood-brain barrier, and cellular uptake facilitate physiologic Aβ clearance. Astrocytes can take up and degrade Aβ, but it remains unclear whether this function is insufficient in AD or can be enhanced to ...
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