Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.
نویسندگان
چکیده
We have identified host IQGAP1 as an interacting partner for Ebola virus (EBOV) VP40, and its expression is required for EBOV VP40 virus-like particle (VLP) budding. IQGAP1 is involved in actin cytoskeletal remodeling during cell migration and formation of filopodia. The physical interaction and the functional requirement for IQGAP1 in EBOV VP40 VLP egress link virus budding to the cytoskeletal remodeling machinery. Consequently, this interaction represents a novel target for development of therapeutics to block budding and transmission of filoviruses.
منابع مشابه
Membrane binding and bending in Ebola VP40 assembly and egress
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ورودعنوان ژورنال:
- Journal of virology
دوره 87 13 شماره
صفحات -
تاریخ انتشار 2013