Caspases: A Potential Therapeutic Targets in the Treatment of Alzheimer’s Disease
نویسنده
چکیده
An enormous body of evidence supports the activation of caspases may be responsible for the neurodegeneration associated with Alzheimer’s disease (AD) and for that reason, caspases are potential therapeutic targets for the management of this disorder. However, till date, the studies testing with prospective role of caspase inhibitors for the treatment of AD have yet to be realized. Obviously, this is due to the potential side effects due to long term use of caspase inhibitors. In addition, a further assessment is warned in relation to the therapeutic efficacy and stress of targeting caspase inhibition with the potential caspase inhibitors and its improved delivery system to the brain in the treatment of AD. *Corresponding author: Dr. Kuladip Jana, Division of Molecular Medicine, Bose Institute, Centenary Campus, P 1/12, Calcutta Improvement Trust Scheme VIIM, Kolkata-700 054, India, Tel: 091-33-25693322/091-9007042850; E-mail: nagi. [email protected]; [email protected] Received Febrauary 19, 2013; Accepted March 27, 2013; Published March 29, 2013 Citation: Jana K, Banerjee B, Pravat Kumar P (2013) Caspases: A Potential Therapeutic Targets in the Treatment of Alzheimer’s Disease. Transl Med S2: 006. doi:10.4172/2161-1025.S2-006 Copyright: © 2013 Jana K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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