Syntheses of aromatic aldehyde imine derivatives of 2-thiobenzyl-1,3,4-thiadiazole and evaluation of their anticonvulsant activity

Benzyl and chlorobenzyl substituted 1, 3, 4-thiadiazole imine derivatives have been prepared by refluxing aromatic aldehyde imine derivatives and benzyl chloride/ 4-chloro benzyl chloride in ethanolic potassium hydroxide. The structures of the compounds have been determined by spectral and chemical methods. The anticonvulsant activity has been carried out using Karl et al. method. All the reported compounds show good anticonvulsant activity wherein chlorobenzyl substituted compounds show potent anticonvulsant activity against phenytoin used as the standard reference drug. Neurotoxicity has been screened through the Rota rod and ethanol potentiation test. The compounds did not show any neurotoxicity.