Borrelia hermsii relapsing fever.

نویسندگان

  • Hubert Felder
  • Kenneth A Hoekstra
چکیده

A 49-year-old healthy female presented to the emergency department with a headache, fever to 103°F, mild myalgia, heart rate of 119 bpm, and blood pressure of 80/40 mm Hg. Past medical history was unremarkable, no drug allergies or current medications, except for a recent vacation in eastern Washington state. The complete blood count showed a white blood cell count of 12.5 3 10E9/L (mild leukocytosis with left shift), thrombocytopenia (32 000/mL), normal electrolytes, and an elevated C-reactive protein (19.8 mg/dL). Blood cultures were sterile. The peripheral blood smear revealed spirochetes morphologically resembling Borrelia species (Borrelia sp) and were considered confirmatory for relapsing fever (RF). Serological testing for Borrelia sp on acute and convalescent specimens exhibited negative and positive immunoglobulin G antibodies to B hermsii, respectively. She was treated with ciprofloxacin and made a full recovery. Although the therapy for tickor louse-borne borreliosis is well established and the response to antibiotics is predictably good, RF is a communicable disease and must be reported by laboratories to the local health department.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Tick-borne Relapsing Fever Caused by Borrelia hermsii, Montana

Five persons contracted tick-borne relapsing fever after staying in a cabin in western Montana. Borrelia hermsii was isolated from the blood of two patients, and Ornithodoros hermsi ticks were collected from the cabin, the first demonstration of this bacterium and tick in Montana. Relapsing fever should be considered when patients who reside or have vacationed in western Montana exhibit a recur...

متن کامل

Identification and characterization of a linear-plasmid-encoded factor H-binding protein (FhbA) of the relapsing fever spirochete Borrelia hermsii.

In North America, tick-borne relapsing fever (TBRF) is caused by the spirochete species Borrelia hermsii, Borrelia parkeri, and Borrelia turicatae. We previously demonstrated that some isolates of B. hermsii and B. parkeri are capable of binding factor H and that cell-bound factor H can participate in the factor I-mediated cleavage of C3b. Isolates that bound factor H expressed a factor H-bindi...

متن کامل

GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis.

Tick-borne relapsing fever is caused by numerous Borrelia species maintained in nature by Ornithodoros tick-mammal cycles. Serological confirmation is based on either an immunofluorescence assay or an enzyme-linked immunosorbent assay using whole cells or sonicated Borrelia hermsii as the antigen. However, antigenic variability of this bacterium's outer surface proteins and antigens shared with...

متن کامل

Isolation and characterization of Borrelia hermsii associated with two foci of tick-borne relapsing fever in California.

Relapsing fever, caused by the spirochete Borrelia hermsii and transmitted by the soft tick Ornithodoros hermsi, is endemic in many rural mountainous areas of California. Between 1996 and 1998, 12 cases of relapsing fever associated with two exposure sites in northern California were investigated. Follow-up at exposure sites included collection of soft ticks and serum specimens from sylvatic ro...

متن کامل

Bloodstream- versus tick-associated variants of a relapsing fever bacterium.

The relapsing fever spirochete, Borrelia hermsii, alternates infections between a mammal and a tick vector. Whether the spirochete changes phenotypically in the different hosts was examined by allowing the tick vector Ornithodoros hermsi to feed on mice infected with serotype 7 or serotype 8 of B. hermsii. Upon infection of ticks, the spirochetal serotype-specific variable major proteins (Vmps)...

متن کامل

Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence

DNA methyltransferases have been implicated in the regulation of virulence genes in a number of pathogens. Relapsing fever Borrelia species harbor a conserved, putative DNA methyltransferase gene on their chromosome, while no such ortholog can be found in the annotated genome of the Lyme disease agent, Borrelia burgdorferi. In the relapsing fever species Borrelia hermsii, the locus bh0463A enco...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Blood

دوره 123 2  شماره 

صفحات  -

تاریخ انتشار 2014