Guidelines on the diagnosis and management of Waldenström macroglobulinaemia.

نویسندگان

  • Roger G Owen
  • Guy Pratt
  • Rebecca L Auer
  • Rita Flatley
  • Charalampia Kyriakou
  • Michael P Lunn
  • Francis Matthey
  • Helen McCarthy
  • Feargal P McNicholl
  • Saad M Rassam
  • Simon D Wagner
  • Matthew Streetly
  • Shirley D'Sa
چکیده

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منابع مشابه

Guidelines on the management of Waldenström macroglobulinaemia.

Waldenström macroglobulinaemia (WM) is a distinct disorder characterised by a monoclonal immunoglobulin (Ig)M paraprotein and morphological evidence of lymphoplasmacytic lymphoma; the cells are IgM+, IgD+, CD19 and CD20 but usually CD5, CD10 and CD23. Therapy should currently be reserved for patients who are symptomatic or in whom there is haematological suppression or clear evidence of disease...

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Waldenström macroglobulinaemia presenting as tingling ulcers on the feet

A 56-year-old man presented with tingling ulcers on the feet. On further skin examination, papules on the knees were observed. Biopsies revealed extravascular eosinophilic deposits of IgM, and Waldenström macroglobulinaemia was diagnosed. The skin manifestations have resolved with chemotherapy. Peripheral neuropathy and storage papules are rare manifestations of Waldenström's macroglobulinaemia.

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Recommendations for the diagnosis and initial evaluation of patients with Waldenström Macroglobulinaemia: A Task Force from the 8th International Workshop on Waldenström Macroglobulinaemia.

The diagnosis of Waldenström macroglobulinaemia (WM) can be challenging given the variety of signs and symptoms patients can present. Furthermore, once the diagnosis of WM is established, the initial evaluation should be thorough as well as appropriately directed. During the 8th International Workshop for WM in London, United Kingdom, a multi-institutional task force was formed to develop conse...

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Investigation and management of IgM and Waldenström-associated peripheral neuropathies: recommendations from the IWWM-8 consensus panel.

Paraproteinaemic neuropathies are a heterogeneous group of disorders most frequently associated with IgM monoclonal gammopathies including Waldenström macroglobulinaemia (WM). Their consequences are significant for affected patients, and their management challenging for their physicians. The variability in clinical presentation and time course hamper classification and management. The indicatio...

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The morphology of the lymph node in the macroglobulinaemia of Waldenström.

In 16 cases of Waldenström's macroglobulinaemia the following findings were sufficiently frequent to justify a provisional diagnosis: a modestly enlarged node with lymphocytic infiltration through the capsule into the adjacent connective tissue, retention of the sinus and medullary reticulin pattern, few or no peripheral follicles, sinuses marked out by pale histiocytes, scanty mitoses, numerou...

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Waldenström's macroglobulinaemia treated with cylophosphamide and chlorambucil.

A case of primary macroglobulinaemia of Waldenström is described in which prolonged treatment with the alkylating agents of cyclophosphamide and chlorambucil led to a sustained reduction in the concentration of circulating macroglobulin together with a concurrent improvement in the patient's symptoms.

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عنوان ژورنال:
  • British journal of haematology

دوره 165 3  شماره 

صفحات  -

تاریخ انتشار 2014