Comparison of Progesterone Alone and Progesterone and Human Chorionic Gonadotrophin in Combination in the Management of Threatened Abortion

Objective: To compare the efficacy of progesterone alone and progesterone plus human chorionic gonadotrophin in the management of threatened abortion. Study design: Quasi experimental Duration & settings of study: The study was conducted in the department of Obstetrics & Gynaecology Unit-I, at Bahawal Victoria Hospital, Bahawalpur from 01-11-2007 to 31-10-2008. Material & method: Total 60 patients admitted with threatened miscarriage at gestational age 5-14 weeks having viable pregnancy were studied .The diagnosis was made on history, examination and viability was confirmed on ultrasonography. Patients were divided into two groups A and B. Group-A was given Progesterone & Group-B was given Progesterone plus hCG .It was observed whether the vaginal bleeding stopped, abdominal discomfort/pain settled and pregnancy continued to second trimester or not. Results: Vaginal bleeding settled in Group-A in 16 (53.33%) and in Group-B 25 (83.33%) patients and in the rest of the patients i.e. 14 (46.67%) in Group-A and 5 (16.67%) in Group-B the bleeding persisted. Abdominal pain/discomfort settled in Group-A 15 (50%) of the patients and in Group-B 25 (83.33%). The most important variable was persistence of pregnancy upto 2 nd trimester. In this study, Group-A, showed persistence of pregnancy upto 2 nd trimester in 17(56.67%) and in Group-B 25(83.33%). Conclusion: Management of threatened abortion with progesterone plus hCG has better outcome as compare to progesterone alone.