Expression status and prognostic value of cancer/testis antigen OY-TES-1 in glioma
نویسندگان
چکیده
Cancer testis (CT) antigens are attractive therapeutic targets for tumor immunotherapy because of their restrictive expression in normal tissues and excessive in majority of tumor types. OY-TES-1 is a member of the cancer/testis (CT) antigen family. Current research about OY-TES-1 expression in glioma is practically at mRNA level. The role of OY-TES-1 protein in glioma has not yet been described. In this study, we detected OY-TES-1 protein expression in 124 samples from patients with glioma by immunohistochemistry and analyzed the correlation between OY-TES-1 expression and clinical indexes. Furthermore, its clinical significance on glioma prognosis was determined by followup data. Our results showed that the OY-TES-1 staining was mainly located in the cell cytoplasm and nucleus and the total positive rate of its protein was 69.35% in 124 isolated tissue samples. OY-TES-1 expression was closely related with the WHO glioma grade. Kaplan-Meier analysis revealed a significant negative correlation between OY-TES-1 expression and survival. OY-TES-1 expression may be a candidate biomarker for prediction of glioma progression and survival of patients.
منابع مشابه
Serum immunoreactivity of cancer/testis antigen OY-TES-1 and its tissues expression in glioma
OY-TES-1 is a member of the cancer/testis antigen family that is expressed in healthy testis tissue and certain types of cancerous tissue. The present study aimed to analyze the expression pattern of OY-TES-1 and serum anti-OY-TES-1 antibody concentration in patients with glioma. OY-TES-1 mRNA was detected in 28/36 (78%) of glioma cases using conventional reverse transcription polymerase chain ...
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