Multiple intracranial arteritis and hypothyroidism secondary to Streptococcus anginosus infection
نویسندگان
چکیده
A 50-year-old Chinese woman reported a sharp paroxysmal headache and abrupt paralysis of the left leg. She then developed ptosis, blurred vision, diplopia and fever. On admission, a neurological examination revealed right III, IV, VI and left V1 cranial nerve palsy, bilateral upper eyelid oedema and left leg monoplegia (Medical Research Council grade 2/5). In addition, a left Babinski sign and nuchal rigidity were observed. Blood tests revealed elevated white cell count (WCC) and a majority of the cells were neutrophils. Lumbar puncture revealed that the WCC (120×10/μL) and protein level (0.79 g/L) of the cerebrospinal fluid (CSF) were slightly elevated, though the intracranial pressure was normal. A cranial MRI showed an infarction in the right corona radiata and base of the skull structures were also involved. MR arteriography indicated that multiple intracranial large arteries were narrowed Figure 1. Moreover, the CSF culture indicated Streptococcus anginosus infection, which was diagnostically very important. Accordingly, the patient was treated with vancomycin, tinidazole, low-molecular-weight heparin calcium and dexamethasone for 2 weeks. She achieved remission of the neurological symptoms but her heart rate gradually slowed (45– 65 bpm) and blood pressure decreased (75–90/45–50 mm Hg). She became depressed and developed apathy towards food. The Mini-Mental State Examination score (23/30) mainly indicated memory deterioration, disorientation and partial acalculia. The results of timely blood pituitary function tests indicated considerably decreased free T3, free T4 and thyroid-stimulating hormone levels, which indicated primary hypothyroidism. After subsequent administration of 12.5 mg/day levothyroxine for 2 months, the patient’s heart rate and blood pressure were normalised and mental status returned to normal. At this point, a CSF bacterial culture established the specific pathogen to be S. anginosus, a member of the Streptococcus milleri group colonising the human oral cavity, pars pharyngeal pharynges. When a healthy individual’s immunity declines, opportunistic infection with S. anginosus may occur. 2 Apart from causing a toothache and headache, the infection may spread intracranially to cause meningitis and cerebral venous system thrombophlebitis. 4 In addition, inflammatory involvement of multiple large arteries, that is, the internal carotid artery (ICA) and its branches, the anterior and middle cerebral arteries—is another rare specific feature secondary to S. anginosus infection. Because the cavernous segment of the ICA courses through the cavernous sinus, S. anginosus infection can also extend to enter the ICA and cause diffuse inflammation of the sinus, which in turn causes thrombosis and narrowing of the ICA and its branches. Inflammation may also spread to the carotid sheath through the parapharyngeal space. Monoplegia and hemiplegia
منابع مشابه
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