Efficacy of condensed tannins against larval Hymenolepis diminuta (Cestoda) in vitro and in the intermediate host Tenebrio molitor (Coleoptera) in vivo.
نویسندگان
چکیده
Natural anti-parasitic compounds in plants such as condensed tannins (CT) have anthelmintic properties against a range of gastrointestinal nematodes, but for other helminths such effects are unexplored. The aim of this study was to assess the effects of CT from three different plant extracts in a model system employing the rat tapeworm, Hymenolepis diminuta, in its intermediate host, Tenebrio molitor. An in vitro study examined infectivity of H. diminuta cysticercoids (excystation success) isolated from infected beetles exposed to different concentrations of CT extracts from pine bark (PB) (Pinus sps), hazelnut pericarp (HN) (Corylus avellana) or white clover flowers (WC) (Trifolium repens), in comparison with the anthelmintic drug praziquantel (positive control). In the in vitro study, praziquantel and CT from all three plant extracts had dose-dependent inhibitory effects on cysticercoid excystation. The HN extract was most effective at inhibiting excystation, followed by PB and WC. An in vivo study was carried out on infected beetles (measured as cysticercoid establishment) fed different doses of PB, HN and praziquantel. There was a highly significant inhibitory effect of HN on cysticercoid development (p=0.0002). Overall, CT showed a promising anti-cestodal effect against the metacestode stage of H. diminuta.
منابع مشابه
Efficacy of condensed tannins against larval Hymenolepis diminuta ( Cestoda ) in 1 vitro and in the intermediate host Tenebrio molitor ( Coleoptera ) in vivo
متن کامل
Sex differences in frass production and weight change in Tenebrio molitor (Coleoptera) infected with cysticercoids of the tapeworm Hymenolepis diminuta (Cestoda)
In their intermediate host, parasites alter aspects of host physiology including waste production and body weight. Further, this alteration may differ between female and male hosts. To study this, a beetle (Tenebrio molitor)-tapeworm (Hymenolepis diminuta) system was used. Infected and uninfected male and female beetles were individually housed in vials without food. Each beetle's weight change...
متن کاملDo male and female beetles (Tenebrio molitor) respond differently to rat feces containing eggs from the tapeworm, Hymenolepis diminuta?
Males and females often differ in their susceptibility and exposure to infection. Thus, they may also differ in their ability to avoid infection. The beetle, Tenebrio molitor, risks infection with cysticercoids when ingesting rat feces containing eggs of the tapeworm, Hymenolepis diminuta. Previous studies demonstrated that beetles sometimes prefer infective feces suggesting that the tapeworm i...
متن کاملIncreased coprophagic activity of the beetle, Tenebrio molitor, on feces containing eggs of the tapeworm, Hymenolepis diminuta.
When provided with fecal pellets from uninfected (control) rats and rats infected with the tapeworm Hymenolepis diminuta, more fed and starved (72 h) female and starved male Tenebrio molitor fed on fecal pellets from infected- than from control rats; compared to fecal pellets from controls rats, fed males avoided the infective fecal pellets. Uninfective and infective fecal pellets had similar m...
متن کاملEstablishment Success of the Beetle Tapeworm Hymenolepis diminuta Depends on Dose and Host Body Condition
Parasite effects on host fitness and immunology are often intensity-dependent. Unfortunately, only few experimental studies on insect-parasite interactions attempt to control the level of infection, which may contribute substantial variation to the fitness or immunological parameters of interest. The tapeworm Hymenolepis diminuta-flour beetle Tenebrio molitor model-has been used extensively for...
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ورودعنوان ژورنال:
- Veterinary parasitology
دوره 207 1-2 شماره
صفحات -
تاریخ انتشار 2015