Health Canada advisory on domperidone should I avoid prescribing domperidone to women to increase milk production [corrected]?
نویسندگان
چکیده
QUESTION I often prescribe domperidone to women as a galactagogue starting at a dose of 30 mg and increasing the dose as needed. In March of this year, Health Canada released an advisory warning of domperidone use and abnormal heart rhythms and sudden cardiac death. Should I cap doses at 30 mg or stop prescribing domperidone all together to these women? ANSWER The Health Canada warning is based on 2 studies. The results of the studies are not directly applicable to breastfeeding and should not change the way you normally manage otherwise healthy breastfeeding women.
منابع مشابه
Effect of Domperidone on Insufficient Lactation in Puerperal Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Background. There is a controversy within the medical community regarding the role of domperidone as a galactagogue and the drug has been removed from the US market owing to safety concerns. Objective. To perform a systematic review and meta-analysis of the available data assessing the effect of domperidone on breast milk production in women experiencing insufficient lactation. Study Selection....
متن کاملEffect of domperidone on milk production in mothers of premature newborns: a randomized, double-blind, placebo-controlled trial.
BACKGROUND Varying degrees of success have been reported with strategies to increase milk production when lactation is failing. The objective of this study was to investigate the efficacy of domperidone in augmenting milk production in mothers of premature newborns. METHODS Twenty patients were randomly assigned to receive either domperidone or placebo for 7 days. Milk volume was measured dai...
متن کاملDomperidone Prescribing Practices Exposed Patients to Cardiac Risk despite a “Black Box” Warning: A Canadian Tertiary Care Center Study
Background. In 2012, Health Canada released a warning regarding domperidone use, based on associations with life-threatening arrhythmias and death. Objective. This study aimed to compare the appropriateness of domperidone prescribing patterns before the advisory to those afterward. Methods. Two retrospective reviews were conducted for patients prescribed domperidone during quarters in 2005 and ...
متن کاملStudy protocol: a double blind placebo controlled trial examining the effect of domperidone on the composition of breast milk [NCT00308334]
BACKGROUND Domperidone, a drug that enhances upper gastric motility, is an anti-dopaminergic medication that also elevates prolactin levels. It has been shown to safely increase the milk supply of lactating women. To date, researchers have analyzed the effects of domperidone on lactating woman with respect to the quantity of their milk production, adverse effects, and drug levels in the breast ...
متن کاملMetoclopramide or domperidone for increasing maternal breast milk output: a randomised controlled trial.
OBJECTIVE To compare the effects of metoclopramide and domperidone on the breast milk output of mothers with infants in neonatal intensive care. DESIGN Double-blind randomised controlled trial. SETTING Tertiary level neonatal intensive care unit (NICU). SAMPLE Eighty mothers expressing breast milk for their infants (mean gestational age 28 weeks) based in NICU and the amounts expressed fe...
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ورودعنوان ژورنال:
- Canadian family physician Medecin de famille canadien
دوره 58 9 شماره
صفحات -
تاریخ انتشار 2012