SnapShot: FMRP mRNA Targets and Diseases
نویسندگان
چکیده
FMRP, or fragile X mental retardation protein is an RNA-binding protein. Mutations in the FMRP protein have been associated with neurological disease as have a number of its mRNA-binding targets. This SnapShot presents 40 bona fide FMRP targets for which mRNA binding and protein regulation have been robustly reported in mammals along with the diseases with which they have been associated.
منابع مشابه
The FMRP regulon: from targets to disease convergence
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in 1991, many studies have primarily focused on understanding the function/s of t...
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ورودعنوان ژورنال:
- Cell
دوره 158 شماره
صفحات -
تاریخ انتشار 2014