An integral-transform approach to the bioheat transfer problems in magnetic hyperthermia

Our purpose in this study was to present an integral-transform approach to the analytical solutions of the Pennes' bioheat transfer equation and to apply it to the calculation of temperature distribution in tissues in hyperthermia with magnetic nanoparticles (magnetic hyperthermia). The validity of our method was investigated by comparison with the analytical solutions obtained by the Green's function method for point and shell heat sources and the numerical solutions obtained by the finite-difference method for Gaussian-distributed and step-function sources. There was good agreement between the radial profiles of temperature calculated by our method and those obtained by the Green's function method. There was also good agreement between our method and the finite-difference method except for the central temperature for a step-function source that had approximately a 0.3% difference. We also found that the equations describing the steady-state solutions for point and shell sources obtained by our method agreed with those obtained by the Green's function method. These results appear to indicate the validity of our method. In conclusion, we presented an integral-transform approach to the bioheat transfer problems in magnetic hyperthermia, and this study demonstrated the validity of our method. The analytical solutions presented in this study will be useful for gaining some insight into the heat diffusion process during magnetic hyperthermia, for testing numerical codes and/or more 3 complicated approaches, and for performing sensitivity analysis and optimization of the parameters that affect the thermal diffusion process in magnetic hyperthermia.