Mantel-Haenszel analyses of litter-matched time-to-response data, with modifications for recovery of interlitter information.
نویسندگان
چکیده
The Mantel-Haenszel procedure for comparing sets of time-to-response data is adaptable to data that can be stratified on other variables. A particular adaptation, which we have used, is one in which animals from the same litter have been assigned to different treatment groups, e.g., some to a control group and some to a drug treatment group. The time to response used was that of tumor appearance; death from other causes was considered a loss to observation. The initial litter-adjusted analysis seemed to have only limited advantages compared to analysis that ignored litters and could be interpreted as suggesting that litter matchihg was not advantageous. Contributing to the difficulty was the fact that in the litter-matched analysis no further information was forthcoming from the remaining similarly treated animals in a litter when there were no remaining contrastingly treated littermates. Several devices for recovering interlitter information from such remnants and for combining it with intralitter information are examined and applied.
منابع مشابه
Use of logrank scores in the analysis of litter-matched data on time to tumor appearance.
Previously, Mantel, Bohidar, and Ciminera (Mantel-Haenszel analyses of litter-matched time-to-response data, with modifi cations for recovery of interlitter information. Cancer Res., 37: 3863-3868, 1977) described how the Mantel-Haenszel method could be applied to litter-matched time-to-tumor data. Each litter would be treated as a separate stratum but only for as long as there remained contras...
متن کاملTHE OCCURRENCE OF ENDOMETRIOSIS AMONG INFERTILE PATIENTS WITH UTERINE MYOMA AND THOSE WITH P OLYC YSTIC OVARIAN DISEASE: COMPARISON WITH INFERTILE CONTROL CASES
In order to determine the occurrence of endometriosis in patients with uterine myoma and in those with polycystic ovarian disease (PCOD) compared to controls, 540 infertile patients were fIrst divided into two age groups of 20-29 and 30-39. Then each group was subdivided to patients with 1) uterine myoma, 2) PCOD, and 3) no uterine myoma or PCOD (control subgroup). The occurrence of endomet...
متن کاملA general estimator for the variance of the Mantel-Haenszel odds ratio.
This commentary presents a new estiof matching variables, unmatched varimator of the variance of the natural log of ables, or both. This notation encompasses the Mantel-Haenszel odds ratio and illusthe full spectrum of matched and untrates its application in typical case-control matched designs. For example, in the pairdesigns. In contrast with any single previmatched study, MI and Mo are alway...
متن کاملEffect of transatlantic transport on reproduction of agouti and nonagouti deer mice, Peromyscus maniculatus.
In conjunction with establishing colonies of deer mice in the UK, effects of transportation on reproduction in agouti (A) and nonagouti (a) deer mice were assessed. Adults were shipped via ground courier and air freight from Northampton, Massachusetts, USA to Sutton Bonington, Leicestershire, England in February and June. Deer mice were paired upon arrival in Sutton Bonington, whereas matched c...
متن کاملA new approach for differential item functioning detection using Mantel-Haenszel methods. The GMHDIF program.
To date, the statistical software designed for assessing differential item functioning (DIF) with Mantel-Haenszel procedures has employed the following statistics: the Mantel-Haenszel chi-square statistic, the generalized Mantel-Haenszel test and the Mantel test. These statistics permit detecting DIF in dichotomous and polytomous items, although they limit the analysis to two groups. On the con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 37 11 شماره
صفحات -
تاریخ انتشار 1977