Chemopreventive effect of green tea catechin on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
نویسندگان
چکیده
Treatments for oral cancer may have significant adverse effect on the patient’s activities of daily living (ADL) and quality of life (QOL). However, foods may offer potential for chemoprevention. In recent years, attention has been focused on the anti-tumor and carcinogenesis-inhibiting actions of green tea. (−)Epigallocatechin-3-gallate (EGCG), the main component of green tea catechins, has been shown to exert a particularly pronounced carcinogenesis-inhibiting effect even among catechins. However, many issues concerning its mechanism remain unclear. Nuclear factor κB (NF-κB) p65 is a protein complex Chemopreventive effect of green tea catechin on rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide
منابع مشابه
Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specific inhibitor, nimesulide.
Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-1-oxide (4-NQO)-induced rat tongue lesions and the postinitiation chemopreventive potential of a selective COX-2 inhibitor, nimesulide (NIM), were examined in Fischer 344 male rats. NIM was administered in the diet at doses of 150, 300, and 600 ppm for 14 weeks after treatment with 25-35 ppm 4-NQO in the drinking water for 12 week...
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Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-1oxide (4-NQO)-induced rat tongue lesions and the postinitiation chemopreventive potential of a selective COX-2 inhibitor, nimesulide (NIM), were examined in Fischer 344 male rats. NIM was administered in the diet at doses of 150, 300, and 600 ppm for 14 weeks after treatment with 25–35 ppm 4-NQO in the drinking water for 12 weeks...
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