Metabolism of a Heterocylclic Amine Colon Carcinogen in Young and Old Rats
نویسندگان
چکیده
St. Louis VA Medical Center (HJA,VML,JW,TVZ) St. Louis, MO 63125 and Division of Geriatric Medicine (HJA,VML,TVZ) and Department of Biochemistry and Molecular Biology (HJA,TVZ) St. Louis University School of Medicine St. Louis, Missouri 63104 and Department of Medicine (FFH) Washington University School of Medicine St. Louis, Missouri 63110 DMD Fast Forward. Published on January 24, 2007 as doi:10.1124/dmd.106.013532
منابع مشابه
Metabolism of a heterocyclic amine colon carcinogen in young and old rats.
The incidence of colon cancer increases with age, and this may be related to altered metabolism and disposition of carcinogens. One such carcinogen implicated in colon cancer is the heterocyclic amine found in well done meat, 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). The purpose of these studies was to determine whether the disposition and metabolism of IQ changes with age, comparing young ...
متن کاملEffects of Timing and Quantity of Chronic Dietary Ethanol Consumption on A/oxy methane-induced Colonie Carcinogenesis and Azoxymethane Metabolism in Fischer 344 Rats1
EpidemiolÃ3gica!studies have shown an association between consump tion of alcoholic beverages and carcinoma of the large bowel, but studies in experimental models of colonie carcinogenesis have yielded conflicting results. We assessed the effects on azoxymethane-induced colonie carci nogenesis of both timing of chronic dietary ethanol consumption relative to carcinogen administration and quanti...
متن کامل2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine induces a higher number of aberrant crypt foci in Fischer 344 (rapid) than in Wistar Kyoto (slow) acetylator inbred rats.
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine carcinogen in the human diet and is a colon carcinogen in the rat. N-Acetyltransferase-2 (NAT2) catalyzes the conversion of PhIP and other heterocyclic amines to a DNA-reactive form. NAT2 has a polymorphic distribution in humans and other mammals, including rats. The rapid NAT2 genotype has been shown...
متن کاملAge-Related Changes in Doxorubicin-Induced Oxidative Damage: Protective and Pretreatment Effects of Short-Term Aerobic Exercise
ABSTRACT Background and Objective: Doxorubicin (DOX) is an effective anticancer drug. It has been shown that a short-term exercise performed prior to DOX-treatment has no effect on cardiotoxicity in young rats. In the present study, old and young rats were evaluated to determine the protective effects of pre-treatment with short-term exercise on D...
متن کاملTitle of dissertation: EFFECT OF AGING ON COLONIC CHEMOPREVENTION BY DIETARY CURCUMIN
Title of dissertation: EFFECT OF AGING ON COLONIC CHEMOPREVENTION BY DIETARY CURCUMIN Youngjoo Kwon, Doctor of Philosophy, 2006 Dissertation directed by: Assistant Professor Bernadene Magnuson Department of Nutrition and Food Science The incidence of cancer is highly dependent on age. The hypothesis of this thesis was that aging may alter the efficacy of dietary chemoprevention. This hypothesis...
متن کامل