Pharmacokinetics and tissue penetration of ciprofloxacin.
نویسندگان
چکیده
A 500-mg dose of the quinoline ciprofloxacin was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and blister fluid were measured. Absorption appeared to be rapid, with a mean peak level of 2.4 micrograms/ml attained 1.25 h after administration. The serum elimination half-life was 3.9 h. The agent penetrated blister fluid well, the percent penetration being 57%. Urinary recovery of ciprofloxacin was 30%.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 24 5 شماره
صفحات -
تاریخ انتشار 1983