Effect of ketoconazole in combination with other inhibitors of sterol synthesis on fungal growth.
نویسندگان
چکیده
The effect of combination of ketoconazole with other sterol synthesis inhibitors on fungal growth was tested against a variety of fungi selected for resistance to ketoconazole. All of the sterol inhibitors, at concentrations lower than their MICs, caused an increase greater than fourfold in the ketoconazole susceptibility of some fungi. Some of the sterol synthesis inhibitors showed this effect with ketoconazole at levels that may be achieved clinically.
منابع مشابه
In vitro and in vivo effects of the antimycotic drug ketoconazole on sterol synthesis.
Ketoconazole, an orally active antimycotic drug, is a potent inhibitor of ergosterol biosynthesis in Candida albicans when added to culture media which support yeast or mycelial growth or to cultures containing outgrown mycelium. This inhibition coincides with accumulation of sterols with a methyl group at C-14 and can thus be attributed to an interference with one of the reactions involved in ...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 28 4 شماره
صفحات -
تاریخ انتشار 1985