Illuminating Hippocampal Control of Fear Memory and Anxiety

نویسندگان

  • Neil M. Fournier
  • Ronald S. Duman
چکیده

Previous reports on dorsal and ventral hippocampal regulation of context learning versus anxiety have been mixed. In this issue of Neuron, a new study by Kheirbek et al. (2013) using optogenetics demonstrates that dentate gyrus granule cell activity in dorsal hippocampus encodes contextual fear learning while ventral granule cell activity regulates anxiety behavior.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Moderate Treadmill Exercise and Fluoxetine on Spatial Memory and Serum BDNF Levels in an Animal Model of Post-traumatic Stress Disorder

Background and purpose: Post-traumatic stress disorder (PTSD) develops after major trauma that is accompanied by certain signs, including pervasive fear memories, anxiety, abnormality in spatial and cognition memory, and decrease in hippocampal brain-derived neurotrophic factor (BDNF). Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for PTSD. This study aimed at inv...

متن کامل

The Roles of Mineralocorticoid and GABA A Receptors in Anxiety and Fear Memory

The purpose of this dissertation was to examine the roles of brain mineralocorticosteroid (MR) and γ-aminobutyric acid (GABAA) receptors in mediating unconditioned fear and fear memory. The first set of experiments explored the role of hippocampal and medial prefrontal cortex mineralocorticosteroid receptors (MRs) in anxiety and fear memory. The MR antagonist RU28318 was microinfused into the d...

متن کامل

Directional Theta Coherence in Prefrontal Cortical to Amygdalo-Hippocampal Pathways Signals Fear Extinction

Theta oscillations are considered crucial mechanisms in neuronal communication across brain areas, required for consolidation and retrieval of fear memories. One form of inhibitory learning allowing adaptive control of fear memory is extinction, a deficit of which leads to maladaptive fear expression potentially leading to anxiety disorders. Behavioral responses after extinction training are th...

متن کامل

The Effect of Gallic Acid on Cognitive Dysfunctions with Intrauterine Growth Restriction in Rats

Background: Intrauterine growth restriction (IUGR) lead to abnormalities in fetal central nervous system, till hippocampal and cortical cells became apoptotic. The goal of this research is investigating the effects of Gallic acid on improvement of cognitive impairments and nuclear factor kappa B (NFƙB) in animal model of IUGR. Material and Methods: In this experimental study, 32 female rats fro...

متن کامل

Effects of Mineralocorticoid Receptors Blockade on FearMemory Reconsolidation in Rats

Reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization. Previous studies have shown that mineralocorticoid receptors (MRs) modulate distinct phases of learning and memory, which display a high concentration and distinct distribution in the hippocampus. Moreover, we found no studie...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Neuron

دوره 77  شماره 

صفحات  -

تاریخ انتشار 2013