Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review: Pyrazolopyrimidine Moiety
نویسندگان
چکیده
Department of Pharmaceutical technology, Meerut Institute of Engineering and Technology, Meerut. ABSTRACT Pyrazole and pyrimidine derivatives attracted organic chemists due to their various biological and chemotherapeutic significance. Pyrazolopyrimidines and related fused heterocycles are of important as probable bioactive molecules. The heterocyclic fusion of pyrimidine ring and pyrazole ring resulted in formation of pyrazolopyrimidines, the structural analogues of biogenic purine class, definitely, has high impact in the field of pharmaceutical and biotechnological sciences with vast spectrum of biological activities. Several pharmacological actvities like mitotic, CNS stimulant, analgesic, antiinflammatory, antiasthmatic, antibacterial and anticancer activity have been attributed. Numerous pyrazolopyrimidine derivatives have been found to possess considerable biolgical activities, which stimulated the research activity ion this field. Pyrazolopyrimidine derivative show inhibitory activity towards both tubulin polymerization and cyclin dependent kinase.
منابع مشابه
Pharma Science Monitor an International Journal of Pharmaceutical Sciences a Review: Chemical Penetration Enhancers
متن کامل
Pharma Science Monitor an International Journal of Pharmaceutical Sciences Development and Optimization of an Economic Method for Quantitation of Azithromycin in Human Plasma by Tandem Mass Spectroscopy (lcms/ms) for Clinical Trials
متن کامل
Synthesis, Characterization, Anticancer, Antibacterial and Antioxidant Evaluation of Macrocyclic Copper (ii) Complexes Derived from Thiosemicarbazide
The " International Journal of Pharma and Bio Sciences " (IJPBS) is an international journal in English published quarterly. The aim of IJPBS is to publish peer reviewed research and review articles rapidly without delay in the developing field of pharmaceutical and biological sciences
متن کاملPharma Science Monitor an International Journal of Pharmaceutical Sciences Process Validation in Pharmaceutical Industry: a Review
Validation is a tool of quality assurance which provides confirmation of the quality in equipment system, manufacturing processes, software and testing methods. Validation assures the products with predetermined quality characteristics and attributes can be reproduced consistently/reproducibly with in the established limits of the manufacturing process operation at the manufacturing site. Valid...
متن کاملPrevention of White Spot Lesion in Orthodontic Patients Using Casein Phosphopeptide-stabilized Amorphous Calcium Phosphate -a Systematic Review
The " International Journal of Pharma and Bio Sciences " (IJPBS) is an international journal in English published quarterly. The aim of IJPBS is to publish peer reviewed research and review articles rapidly without delay in the developing field of pharmaceutical and biological sciences And indexed/catalogued in many more university
متن کامل