Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex.
نویسندگان
چکیده
A dinuclear Cu(II) complex, [Cu(2)(μ-IDA)(phen)(3)(NO(3))]NO(3)·4H(2)O (phen = 1,10-phenanthroline, H(2)IDA = iminodiacetic acid), was found to potently and selectively inhibit T-cell protein tyrosine phosphatase, and lead to the anti-proliferation and apoptosis of C6 glioma cells.
منابع مشابه
The YRD motif is a major determinant of substrate and inhibitor specificity in T-cell protein-tyrosine phosphatase.
We have studied T-cell protein-tyrosine phosphatase (TCPTP) as a model phosphatase in an attempt to unravel amino acid residues that may influence the design of specific inhibitors. Residues 48--50, termed the YRD motif, a region that is found in protein-tyrosine phosphatases, but absent in dual-specificity phosphatases was targeted. YRD derivatives of TCPTP were characterized by steady-state k...
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 8 شماره
صفحات -
تاریخ انتشار 2012