Orally administered marine (1→ 3)- -d-glucan Phycarine stimulates both humoral and cellular immunity
نویسندگان
چکیده
Vaclav Vetvicka a,∗, Bohuslav Dvorak b, Jana Vetvickova a, Jan Richter c, Jiri Krizan c, Petr Sima c, Jean-Claude Yvin d a University of Louisville, Department of Pathology, Louisville, KY 40202, United States b University of Arizona, Department of Pediatrics, Tucson, AZ 85724, United States c Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic d Laboratories Goemar, Saint-Malo, France
منابع مشابه
Orally administered marine (1-->3)-beta-D-glucan Phycarine stimulates both humoral and cellular immunity.
(1-->3)-beta-D-Glucans represent highly conserved structural components of cell walls in yeast, fungi, or seaweed. However, it is still unknown how they mediate their effects. The aim of this study was to evaluate both intraperitoneal and oral application of seaweed-derived (1-->3)-beta-D-glucan Phycarine. Phycarine showed significant stimulation of phagocytosis by peripheral blood cells. In ad...
متن کاملComparison of the effect of orally administered soluble beta-(1-3),(1-6)-D-glucan and of G-CSF on the recovery of murine hematopoiesis.
Beta-glucans are branched fungal polysaccharide compounds with pleiotropic activating effects on cells of the immune and the hematopoietic system. In this study, the hematopoiesis-promoting effect of an orally administered soluble beta-(1-3),(1-6)-D-glucan and of intravenously (i.v.) injected recombinant human granulocyte colony-stimulating factor (G-CSF/filgrastim) was tested in cyclophosphami...
متن کاملReactivity of the immunological system of rats stimulated with Biolex-Beta HP after cyclophosphamide immunosuppression
The objective of this study was to determine the stimulating effect of the Biolex-Beta HP (β-1,3/1,6-D-glucan) dietary supplement on selected parameters of specific and non-specific humoral and cellular immunity in rats immunosuppressed with cyclophosphamide. The experimental material comprised 40 Wistar rats, divided into two equal groups: control and experimental. In the course of 3 successiv...
متن کاملOrally administered particulate beta-glucan modulates tumor-capturing dendritic cells and improves antitumor T-cell responses in cancer.
PURPOSE The beneficial properties of β-glucans have been recognized for centuries. Their proposed mechanisms of action in cancer therapy occur via stimulation of macrophages and priming of innate neutrophil complement receptor 3 for eliciting complement receptor 3-dependent cellular cytotoxicity of iC3b-opsonized tumor cells. The current study is to investigate whether β-glucan therapy has any ...
متن کاملOrally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice.
We have previously demonstrated that subcutaneously administered ovalbumin (OVA) plus synthetic oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG-ODN) as adjuvant stimulate cellular and humoral immunity and promote T helper cell type 1 differentiation in aged mice. The present study assessed the ability of CpG-ODN to induce an OVA-specific immune response after oral immunizatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2007